Endocrine Abstracts

Myelolipomas are rare benign tumours resulting from myeloid and adipose mature cells proliferation, both elements have a clonal origin from a common precursor. Myelolipomas predominantly involve the adrenal gland but may develop in extra-adrenal sites. They are hormonally inactive but may coexist with active diseases such as adrenogenital syndrome. They are often asymptomatic but rarely they cause symptoms due to their size or spontaneous retroperitoneal haemorrhage. The myelo...

Animal and observational studies suggest that the IGF axis is involved in the pathogenesis of ischemic stroke; moreover, endogenous IGF-I could influence the evolution of ischemic stroke in humans and thereby contribute to an improved clinical and functional outcome. To assess and correlate the IGF-I axis with biochemical parameters in young patients experiencing ischemic stroke (32 aged 15–45 years,19F, BMI: 25.5±3.4 kg/m2), we evaluated IGF-I, IGFBP-3, A...

Objectives: Erectile dysfunction (ED) is often associated with a wide array of psychiatric symptoms, although few studies systematically address their specific association with ED determinants. Aim of this study is to explore the relationship between ED and different psychopathological symptoms.Design and methods: A consecutive series of 1388 (mean age 51±13 years) male patients with ED was studied. Several hormonal and biochemical parameters were i...

The intensive physical activity is often associated with cardiac changes, particularly involving the right ventricular (RV) chamber. However, the molecular mechanisms involved in the RV physiologic adaptation to long-term training are not completely understood. In the present study we investigated the role of the growth hormone/insulin like growth factor 1 (GH/IGF-1) axis in the RV remodeling of athletes.Nineteen male top levels rowers and 19 age-matched...

Acromegaly is amongst other symptoms associated with myopathy, alterations of energy expenditure and insulin action which are mediated by growth hormone (GH) and insulin-like growth factors (IGFs). It is unclear to which extent these abnormalities remain after treatment. Thus, we examined glucose metabolism, intracellular fat deposition and mitochondrial function in patients with prior acromegaly (AM).Six AM (4f/2 m, age: 49±10 years, body mass inde...

Background: Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is a new method employed in the management of differentiated thyroid cancer (DTC). The integrated FDG-PET plus computed tomography (PET/CT) fusion imaging system seems able to provide some additional advantages over PET alone, mainly related to a better anatomical localisation of the hypermetabolic metastatic lesions. The influence of serum TSH levels on 18F-FDG uptake by recurrences o...

The insecticide DDT has been shown to inhibit both the basal and the TSH stimulated accumulation of cAMP in CHO stably transfected with the TSHr (CHO-TSHr). Aim of this study was to evaluate whether the DDT has a similar effect on cells transfected with TSHr mutants displaying a high level of constitutive activity. In addition we investigate the effect of DDT on cells transfected with wtFSHr and wtLHr which share a high degree of amino-acid homology sequence with wtTSHr. In co...

Induced radiofrequency thermal ablation is cytoreductive treatment of symptomatic benign thyroid nodules, metastatic and recurrent thyroid tumors and papillary thyroid microcarcinomas. It is a safe and effective alternative to surgery and it allows to obtain satisfactory results in terms of volumetric reduction of the nodule with significant improvement in the quality of life. The trans-isthmic approach and the moving shot technique are the two basic techniques; however, an ad...

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. We tested the hypothesis that the matrix protein osteocalcin (OC), secreted by osteoblasts, may modulate parathyroid function. In human parathyroid cells derived from adenomas (PAds), incubation with g-carboxylated OC (GlaOC) or undercarboxylated OC (GluOC) modulated the intracellular signaling pathways: both GlaOC and GluOC inhibited the basal phosphor...

Background: The 2022 WHO Classification of Endocrine and Neuroendocrine Tumors has introduced, as other neuroendocrine neoplasms, new pathological features to classify medullary thyroid carcinoma (MTC) in low/high grade. However, whether it can be reliable in clinical practice should be confirm by further studies.Aim: To verify the predictive value of the 2022 WHO grading system in patients with MTC.Materials and Methods: Tumor tis...